An Analytical Approach to the Protein Designability Problem
arXiv:cond-mat/9904377 · doi:10.1103/PhysRevLett.83.4437
Abstract
We present an analytical method for determining the designability of protein structures. We apply our method to the case of two-dimensional lattice structures, and give a systematic solution for the spectrum of any structure. Using this spectrum, the designability of a structure can be estimated. We outline a heirarchy of structures, from most to least designable, and show that this heirarchy depends on the potential that is used.
16 pages 4 figures