A Continuous Model of Cortical Connectivity

Abstract

We present a continuous model for structural brain connectivity based on the Poisson point process. The model treats each streamline curve in a tractography as an observed event in connectome space, here a product space of cortical white matter boundaries. We approximate the model parameter via kernel density estimation. To deal with the heavy computational burden, we develop a fast parameter estimation method by pre-computing associated Legendre products of the data, leveraging properties of the spherical heat kernel. We show how our approach can be used to assess the quality of cortical parcellations with respect to connectivty. We further present empirical results that suggest the discrete connectomes derived from our model have substantially higher test-retest reliability compared to standard methods.

Accepted at MICCAI 2016